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Reduction of estradiol 3-methyl ether by lithium and gaseous ammonia
Authors:J F Fisher  L L Smith
Affiliation:1. Department of Natural Resource Sciences, McGill University, 21111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec H9X 3V9, Canada;2. Saint-Lawrence Action Plan, Environmental Protection Operations Directorate, Environment and Climate Change Canada, 1550 Avenue d''Estimauville, Québec, Québec G1J 0C3, Canada;3. Aquatic Contaminants Research Division, Science and Water Technology Directorate, Environment and Climate Change Canada, 105 McGill Street, Montréal, Québec H2Y 2E7, Canada
Abstract:Estradiol methyl ether is reduced by lithium and gaseous ammonia in much the same way as by lithium and liquid ammonia, to 3-methoxyestra-2,5(10)-dien-17β-ol, which, on hydrolysis in the usual manner affords 19-nortestosterone.
Keywords:
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