Human brain and spinal cord scan after intracerebroventricular administration of iodine-123 morphine |
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| Affiliation: | 1. Service Central de Médecine Nucléaire, CHU Purpan, 31052 Toulouse Cedex, France;2. Service de Médecine Nucléaire, CHU Rangueil, Toulouse France;3. Clinique de Neurochirurgie, CHU Rangueil, Toulouse, France;1. Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warszawa, Poland;2. University of Social Sciences and Humanities, Warszawa, Poland;1. Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA;2. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA;1. Graduate School of Biomedical Science and Engineering, Hanyang University College of Medicine, 17 Haengdang-dong, Sungdong-gu, Seoul 133-791, Republic of Korea;2. Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, 17 Haengdang-dong, Sungdong-gu, Seoul 133-791, Republic of Korea;1. Department of Psychiatry, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, United States;2. Center for the Study of Traumatic Stress, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, United States;3. Daniel K. Inouye Graduate School of Nursing, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, United States;4. National Capital Consortium Psychiatry Residency Program, Walter Reed National Military Medical Center, Bethesda, MD 20814, United States;1. VIB Center for Inflammation Research, VIB, B-9052 Ghent, Belgium;2. Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium;3. Department of Pathology, Bacteriology and Avian Diseases, Ghent University, B-9820 Merelbeke, Belgium;4. Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, B-2610 Antwerp, Belgium |
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| Abstract: | [123I]iodomorphine (IMPH) was administered intracerebroventriculary (i.c.v.) in eight patients treated by i.c.v. morphinotherapy (i.c.v.m.). Scans obtained by γ-scintigraphy over 1 h post-injection showed only a slight diffusion of IMPH beyond the ventricular system, particular attention being paid to the spinal cord.These data agree well with induced i.c.v.m. analgesia (mean latency 20 min) and biological results such as HPLC assay of morphine in the lumbar cerebrospinal fluid, supporting the action of morphine only on the central opiate receptors. |
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