Rubidium and zinc fluctuations in selected tissues during the development of the BW7756 murine hepatoma |
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| Affiliation: | 1. Faculty of Health Sciences, University of Sydney, 75 East Street, Lidcombe, NSW, 2141, Australia;2. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, 600 N. Wolfe Street, 21287, Baltimore, MD, USA;3. School of Clinical Sciences, Queensland University of Technology, 2 George St, Brisbane, QLD, 4000, Australia;4. University of the Philippines, Pedro Gil Street, Ermita, Manila, 1000, Philippines;1. Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden;2. Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden;1. Institute for Health Transformation, Deakin University, Australia;2. Institute for Health Transformation, Faculty of Health, Deakin University, Australia;3. Department of Psychiatry, The University of Melbourne, Australia;4. Faculty of Business and Law, University of Wollongong, Australia;5. Faculty of Health Sciences, Curtin University, Australia |
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| Abstract: | In separate studies, radioisotopes 65Zn and 86Rb were used to monitor trace element fluctuations from normal in C57L/J mice throughout the progression of a murine hepatoma. Amounts too small to upset normal levels were injected directly into the blood stream. After an equilibration period, the whole mouse and various resected organs and tissues were counted. Compared to normal levels, rubidium in diseased mice was lower in kidney and blood, and elevated in skin and muscle. Diseased mice showed depressed levels of zinc in skin and muscle. Large fluctuations during different stages of tumor growth were observed for various other tissues and organs of diseased mice. |
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