The relaxing effect of SCH 23390 in the molluscan smooth muscle |
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| Affiliation: | 1. Translational Neurosciences and Peripheral Neuropathy Group, University of Antwerp, Antwerp, Belgium;2. Laboratory of Neuromuscular Pathology, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium;3. Department of Neurology, Neuromuscular Reference Centre, Antwerp University Hospital, Antwerp, Belgium;4. Department of Neurology, Onze-Lieve-Vrouwziekenhuis, Aalst, Belgium;5. Department of Rheumatology, Onze-Lieve-Vrouwziekenhuis, Aalst, Belgium;1. Center for Neuropathology and Prion Research, Faculty of Medicine, LMU Munich, Feodor-Lynen-Strasse 23, 81377 Munich, Germany;2. Department of Neuropathology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany;3. Department of Neuropathology, Universitätsmedizin Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany;4. Department of Rheumatology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany;5. Division of Rheumatology and Systemic Inflammatory Diseases, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany |
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| Abstract: | 1. SCH 23390 (SCH, R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine) produced the relaxation of ACh-induced contraction in the anterior byssus retractor muscle of Mytilus edulis (ABRM) in a dose-dependent manner between 10−9-10−6M.2. The dose-response curve of SCH was shifted in parallel to the right by ketanserin (KET) with pA2 value of 5.14 ± 0.08 and by 1-(1-naphthyl)piperazine (NAP) with that of 5.06 ± 0.01, but not by cyproheptadine (CYP), mianserin (MIA), butaclamol (BUTA), ICS 205–930 (ICS) and MDL 72222 (MDL) at 3 × 10−5 M.3. α-Methyl-serotonin (α-Me-5-HT), a selective 5-HT2 receptor agonist dose-dependently relaxed the ACh-induced contraction of ABRM. The dose-response curve of α-Me-5-HT was shifted in parallel to the right by KET with pA2 value of 5.01 ± 0.02, but not by BUTA, CYP, MIA, ICS and MDL at 3 × 10−5 M.4. These findings suggest that 5-HT2-like receptors exist in the ABRM, and that the relaxation induced by SCH is mediated through these receptors. |
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