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Effects of lead exposure on cAMP and correlated enzymes in Viviparus ater (Mollusca gastropoda) nervous system |
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| Affiliation: | 1. Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand;2. Center of Excellence for Medical Genomics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand;3. Excellence Center for Medical Genetics, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok 10330, Thailand |
| Abstract: | 1. The possible interaction of lead with cAMP metabolism has been studied in vivo and in vitro in the ganglionic complex of Viviparus ater (Mollusca Gastropoda) by histochemical and biochemical assays.2. In vivo Pb2+ exposure inhibited adenylate cyclase and cAMP-phosphodiesterase activities in the CNS of V. ater; cAMP levels and responsiveness of the system to 5-HT were unchanged.3. In vitro Pb2+ treatment did not affect adenylate cyclase but enhanced cAMP-phosphodiesterase activity. The responsiveness of cAMP system to 5-HT was reduced by higher Pb2+ concentrations.4. The ganglionic neurons seem to be able to counteract the effects of short-term acute lead exposure maintaining constant the intracellular cAMP concentration. |
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