Glutathione,cysteine and acid-soluble thiol levels in Euglena gracilis cells exposed to copper and cadmium |
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| Affiliation: | 1. Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Indonesia;2. Department of Health Promotion, Faculty of Public Health, Hasanuddin University, Indonesia;3. Department of Environmental Health, Faculty of Public Health, Hasanuddin University, Indonesia;1. Department of Biology, McMaster University, Hamilton, ON, L8S 4K1, Canada;2. Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada |
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| Abstract: | 1. The trend of the total acid-soluble thiols (AST) levels including glutathione (both in reduced form, GSH, and in the oxidized one, GSSG) and free cysteine (CySH) has been studied in Euglena gracilis cells exposed to copper or cadmium up to the fifth day of growth.2. The copper does not affect the levels of AST and of glutathione. A limited increase of CySH is observed during the first days of growth. This is followed by a gradual depletion for longer times.3. The exposure to cadmium leads to an increase in the content of AST as well as of glutathione and CySH levels according to the metal dose and to the exposure time.4. The data are interpreted taking into account the previous observations on the responses of Euglena gracilis to exposure to heavy metals. |
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