Actions of adenylyl compounds in the pedal disc of the cnidarian Actinia equina |
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| Affiliation: | 1. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan, ROC;2. Division of Electrical and Electronic Engineering, School of Engineering, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, United Kingdom;3. Precision Analysis and Materials Research Centre, National Taipei University of Technology, Taipei 106, Taiwan, ROC;4. Chemistry Department, College of Science, Sultan Qaboos University, P.O. Box 36, Postal code Al-Khoudh 123, Muscat, Oman;1. Biological Institute, Tomsk State University, Tomsk, Lenina Ave., 36, 634050, Russian Federation;2. Laboratory for Laser Molecular Imaging and Machine Learning, Tomsk State University, Lenina Ave., 36, 634050, Russian Federation;3. School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia |
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| Abstract: | 1. The actions of adenylyl compounds were investigated in the circular muscle of the pedal disc of the sea anenome Actinia equina.2. Adenosine, adenosine 5'-diphosphate and adenosine 5'-triphosphate (ATP), but not adenosine 5'-monophosphate or the analogues of ATP, α,β-methylene ATP, and 2-methylthio ATP, caused concentration-dependent contractions.3. Neurogenic contractions in response to electrical field stimulation were not consistently affected by any of the adenylyl compounds and could be either potentiated or almost abolished by them.4. Reactive Blue 2, a vertebrate P2-purinoceptor antagonist, caused concentration-dependent contractions which were mediated by nerves, being blocked by the anaesthetic chlorobutanol.5. The pharmacological profile of the adenylyl compounds in the pedal disc of Actinia equina is different from that observed in other invertebrate species and adds to the greater diversity of such profiles in invertebrates than in vertebrates. |
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