Virus-induced alterations of lymphoid tissues. II. Lymphocyte receptors for Newcastle disease virus |
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| Authors: | J F Woodruff J J Woodruff |
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| Affiliation: | 1. Department of Pathology, Cornell University Medical College, New York, New York, 10021 USA;2. Department of Microbiology and Immunology, Downstate Medical Center, Brooklyn, New York, 11203 USA |
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| Abstract: | Newcastle disease virus (NDV) agglutinates rat, mouse and human lymphocytes. Viral agglutination of rat thoracic duct lymphocytes was specifically inhibited by N-acetylneuraminic acid implying that the receptors terminate in sialic acid. While the attachment of virus to lymphocytes was rapid the reaction was unstable and NDV was shown to elute at 37 °C. Evidence was obtained that the eluting virus cleaved sialic acid from the surface of lymphocytes and concomitantly destroyed this lymphocyte receptor. |
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