New structures of allosteric proteins revealing remarkable conformational changes |
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Authors: | Andrea Mattevi Menico Rizzi Martino Bolognesi |
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Affiliation: | aDepartment of Genetics &; Microbiology, University of Pavia, via Abbiategrasso 207, 27100 Pavia, Italy;bDepartment of Physics and IST Advanced Biotechnology Centre, University of Genova, Largo Benzi 10, 16132 Genova, Italy |
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Abstract: | New three-dimensional structures of allosteric proteins reveal they have a flexible architecture that is instrumental to the regulation of protein function. Highlights are the structures of GroEL, pyruvate kinase, -3-phosphoglycerate dehydrogenase and the acetylcholine receptor. Furthermore, significant progress in understanding the nature of the intermediates involved in an allosteric reaction has been achieved through recent spectroscopic and crystallographic studies on haemoglobin. |
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Keywords: | Abbreviations: CO carbon monoxide Hb haemoglobin |
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