Predictions of Backbone Conformational Changes in Abnormal Haemoglobins |
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| Authors: | BARBARA W. LOW ROSE D. SPITZ |
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| Affiliation: | 1.Department of Biochemistry,College of Physicians and Surgeons, Columbia University,New York;2.Barnard College, Columbia University,New York |
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| Abstract: | THE structural effects of amino-acid residue replacement in some thirty-five mutant haemoglobins have been discussed by Perutz and Lehmann1, who consider the perturbations which side-chains of different size, shape and charge introduce into the normal local stereochemistry. |
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