The biological role of mucins in cellular interactions and immune regulation: prospects for cancer immunotherapy |
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| Institution: | 1. Biomira Inc., 2011 94 Street, Edmonton, T6N 1H1, Canada.;2. Department of Biochemistry and Molecular Biology, Mayo Medical and Graduate School Consultant Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA.;3. Biomira, 2011 94 Street, Edmonton, Canada T6N 1H1.;1. Department of Orthopaedics, Burjeel Hospital for Advanced Surgery, Dubai, UAE;2. Department of Orthopaedics and Traumatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania;1. Tianjin Medical University General Hospital, Tianjin 300052, China;2. Tianjin Neurological Institute, Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin 300052, China;3. Clinical Medical College, Hebei University, Baoding 071000, China;4. Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China;5. Department of Neurosurgery, Haikou Affiliated Hospital of Xiangya Medical College, Central South University, Hainan 570311, China;6. Department of Neurosurgery, Haikou People’s Hospital, Hainan 570208, China |
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| Abstract: | Among the human mucins, MUC1 is unique in its cell-surface transmembrane expression and its apparent signal-transduction functions. The high expression of MUC1 on many human cancers makes it an attractive target for immunotherapy. Immunization of human cancer patients with MUC1 peptides has resulted in the generation of both anti-MUC1 antibody and cytotoxic T lymphocyte responses. Recently, a novel immunoregulatory role for MUC1 has been suggested by experiments demonstrating that soluble MUC1 induces T-cell unresponsiveness, and that T cells appear to express and secrete MUC1 following their activation. MUC1 is an apparent paradox, having both adhesive and antiadhesive functions, and immunostimulatory and immunosuppressive activities. |
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