Aspirin as a cancer-preventing drug |
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| Affiliation: | 1. Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, 0379, Oslo, Norway;2. Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany;3. Data Mining and Uncertainty Quantification (DMQ), Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany;4. Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Finland;5. Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland;6. Applied Tumor Genomics, Research Program Unit, University of Helsinki, Helsinki, Finland;7. Division of Cancer and Genetics, Institute of Medical Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK;8. Department of Clinical Genetics, Aalborg University Hospital, 9000, Aalborg, Denmark;9. Department of Biomedicine, Aarhus University, DK-8000, Aarhus, Denmark;10. Department of Surgical Gastroenterology, Aalborg University Hospital, Aalborg University, 9100, Aalborg, Denmark;11. Department of Clinical Medicine, Aalborg University Hospital, Aalborg University, 9100, Aalborg, Denmark;12. Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, 3010, Victoria, Australia;13. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107, Leipzig, Germany;14. Institute of Human Genetics, National Center for Hereditary Tumor Syndromes, Medical Faculty, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany;15. Department of Clinical Genetics, Leids Universitair Medisch Centrum, 2300RC, Leiden, the Netherlands;p. Hereditary Cancer Program, Institut Català d’Oncologia-IDIBELL, L; Hospitalet de Llobregat, 08908, Barcelona, Spain;q. Gastroenterology Department, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain;r. Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK;s. Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK;t. Campus Innenstadt, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, 80336, Munich, Germany;u. Center of Medical Genetics, 80335, Munich, Germany;v. Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology, Fondazione IRCCS Instituto Nazionale dei Tumori, IRCCS, 20141, Milan, Italy;w. Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, 20141, Milan, Italy;x. Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden;y. Service High Risk GI Cancer Gastroenterology, Department Rabin Medical Center, Israel;z. Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia;11. Department of Medicine, University of Melbourne, Melbourne, Australia;12. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands;13. Department of Medicine and Surgery, Laboratory of Molecular Gastroenterology, IRCCS Humanitas Research Hospital, University of Parma, Parma, Italy;14. Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay;15. Medical Genetics, Institute for Medical Genetics and Pathology, University Hospital Basel, Switzerland;16. Department of Genetics and Pathology, International Hereditary Cancer Center, ul. Unii Lubelskiej 1, 71-252, Szczecin, Poland;17. Department of Medicine and Surgery, University of Milan Bicocca, A.O. San Gerardo, Clinic of Obstetrics and Gynecology, Via Pergolesi 33, Monza (MB), Italy;18. Clínica Universidad de los Andes, Chile;19. Department of Gastroenterology, Hadassah, Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel;110. Hadassah Medical Center, Israel;111. Hereditary Cancer Program (PROCANHE) Hospital Italiano de Buenos Aires, Argentina;112. Clinical and Functional Genomics Group, A.C.Camargo Cancer Center, Sao Paulo, Brazil;113. Lynch Syndrome & Family Cancer Clinic, St Mark''s Hospital, Harrow, HA1 3UJ, London, UK;114. Gastrointestinal Cancer Prevention Unit, Gastroenterology Department, Rambam Health Care Campus, Haifa, Israel;115. St Vincent''s University Hospital, Ireland;1p. Department of Gastroenterology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Israel;1q. Foundation for Research in Genetics and Endocrinology, Institute of Human Genetics, FRIGE House, Ahmedabad, 380015, India;1r. Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Southern Israel, Israel;1s. University of Vermont, Larner College of Medicine, Burlington, VT, 05405, USA;1t. Hospital Sirio Libanes, Sao Paulo, Brazil;1u. University of Tolima, Tolima, Colombia;1v. Gastroenterology and Gastrointestinal Endoscopy Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, 20132, Milan, Italy;1w. Surgical Pathology, Instituto Nacional de Cancerologia, Mexico City, Mexico;1x. Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland;1y. Ospedale di Circolo ASST Settelaghi, Centro di Ricerca tumori eredo-familiari, Università dell’Insubria, Varese, Italy;1z. Universidade Federal de Bahia, Bahia, Brazil;21. St Mark''s Hospital, Department of Surgery and Cancer, Imperial College London, London, UK;22. Fundación para el Progreso de la Medicina” y “Sanatorio Allende”, Córdoba, Argentina;23. Hospital Universitário Oswaldo Cruz, Universidade de Pernambuco, Recife, Brazil;24. 1st Department of Surgery, Semmelweis University, Hungary;25. Department of Medical Oncology, University Clinical Hospital of Santiago de Compostela (SERGAS); Translational Medical Oncology Group (Oncomet), Health Research Institute of Santiago de Compostela (IDIS); Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela (USC), 15706, Santiago de Compostela, Spain;26. Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland;27. Department of Education and Science, Central Finland Health Care District, Jyväskylä, Finland;28. Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland;29. The Danish HNPCC Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark;210. Department of Urology, Aarhus University Hospital, Denmark;211. Department of Surgery and Transplantation, Rigshospitalet, Copenhagen University Hospital, Denmark;212. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia;213. Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University, USA;214. Department of Health Science Research, Mayo Clinic Arizona, USA;215. Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Canada;2p. University of Hawaii Cancer Center, USA;2q. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA;2r. Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia;2s. University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia;2t. Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia;2u. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA;2v. Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany;2w. Institute of Human Genetics, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Germany;2x. National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany;2y. Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany;2z. Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany;31. Department of Internal Medicine, University Hospital Bonn, Bonn, Germany;32. Institute of Pathology, Faculty of Medicine and University Hospital Cologne, Cologne, Germany;33. Technische Universität Dresden, Dresden, Germany;34. Centre for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway;35. Centre for Cancer Cell Reprogramming (CanCell), Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway;36. Department of Surgery, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, London, UK;37. Gynaecological Oncology Research Group, Manchester University NHS Foundation Trust, Manchester, UK;38. Division of Obstetrics and Gyneacology, Department of Women''s and Children''s Health, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden;39. Head Adult Genetic Service, Raphael Recanati Genetic Institute, Rabin Medical Center–Beilinson Hospital, Petach Tikva, Israel;310. Sushrut Hospital and Research Centre, Mumbai, India;311. Zydus Cancer Centre, Ahmedabad, India;312. Instituto de Medicina Traslacional e Ingenieria Biomedica (IMTIB), CONICET IU, Hospital Italiano de Buenos Aires, Buenos Aires, 94, Argentina;313. Hospital Privado Universiatrio de Córdoba, Cordoba, Argentina;314. Surgical Center for Hereditary Tumors, Ev. Bethesda Khs Duisburg, University Witten-Herdecke, Herdecke, Germany;315. Department of Medicine, Melbourne University, Melbourne, Australia;3p. Programa Cáncer Heredo Familiar, Santiago, Chile;3q. Depart-ment of Surgery, Universitätsmedizin Mainz, Germany;3r. SEQUIPE, Recife, Brazil;3s. Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029, Madrid, Spain;3t. Department of Surgery, Central Finland Health Care District, Jyväskylä, Finland;3u. Cooperation Unit Applied Tumour Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany;3v. German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany;3w. Institute for Clinical Genetics, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany;3x. Hereditary Cancer Syndrome Center Dresden, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany;3y. MGZ - Medical Genetics Center, Munich, Germany;3z. Division of Cancer Sciences, University of Manchester, Manchester, UK;1. Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa;2. HIV Pathogenesis Program, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa;3. School of Chemistry and Physics, University of KwaZulu-Natal, Durban, 4001, South Africa;4. Faculty of Science and Agriculture, Department of Chemistry, University of Zululand, KwaDlangezwa, 3886, South Africa;1. Duke University Medical Center, Durham, NC, USA;2. Memorial Sloan Kettering Cancer Center, New York, NY, USA;3. Department of Oncology and Hemato-Oncology, Università degli Studi di Milano and Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy;4. Sorbonne Université and Hôpital Saint-Antoine, Paris, France;5. Dana-Farber Cancer Institute, Boston, MA, USA;6. University Hospitals Gasthuisberg–Leuven & KU Leuven, Leuven, Belgium;7. Mayo Clinic Cancer Center, Phoenix, AZ, USA;8. Texas Oncology-Baylor Charles A Sammons Cancer Center, Dallas, TX, USA;9. Mayo Clinic Rochester, Rochester, MN, USA;10. Fred Hutchinson Cancer Center, Seattle, WA, USA;11. Division of Gastrointestinal Medicine, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA;12. Oregon Health & Science University, Portland, OR, USA;13. Weill Cornell Medicine, New York, NY, USA;14. USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA;15. Vanderbilt University Medical Center, Nashville, TN, USA;p. Vall d''Hebron Barcelona Hospital Campus, Vall d''Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain;q. Case Western Reserve University–University Hospitals Cleveland Medical Center, Cleveland, OH, USA;r. Azienda Ospedaliero–Universitaria Pisana and Università di Pisa, Pisa, Italy;s. Aurora Research Institute Cancer Center, Milwaukee, WI, USA;t. Seagen, Bothell, WA, USA;u. Mayo Clinic Arizona, Phoenix, AZ, USA;1. Amity Institute of Biotechnology, Amity University, Sector 125, Noida, Uttar Pradesh 201301, India;2. Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chennai, India;3. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway |
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| Abstract: | Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selectionRuschoff, J. et al. (1998)Proc. Natl. Acad. Sci. U. S. A. 95, 11301–11306 |
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