Glutathione-dependent regulation of platelet aggregation with neutrophils and tumor cells |
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| Authors: | I V Gorudko E V Shamova L M Shishlo A V Mukhortova V I Prokhorova O M Panasenko S A Gusev S N Cherenkevich |
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| Institution: | 1.Belarusian State University,Minsk,Belarus;2.Aleksandrov N.N. National Cancer Center of Belarus,Minsk,Belarus;3.Research Institute of Physico-Chemical Medicine,Moscow,Russia |
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| Abstract: | It is shown that in the presence of reduced glutathione at low concentrations (1–5 μM) the extent of platelet aggregation
with neutrophils increases and the lag period of platelet aggregation induced by tumor cells decreases. At the same time in
the presence of reduced glutathione at high concentration (3 mM) the extent of platelet aggregation with neutrophils decreases,
and the lag period of platelet aggregation induced by tumor cells increases. It is established that glutathione-dependent
regulation of the intercellular contact formation between platelets and neutrophils depends on the ratio of glutathione oxidized
and reduced forms: at fixed total glutathione concentration of 5 μM, increase of glutathione redox potential from −175 mV
to 0 mV led to reduction in platelet aggregation with neutrophils. Thus, it is shown for the first time, that GSH has priming
effect on the platelet aggregation with neutrophils and tumor cells, which may contribute to the regulation of inflammatory
diseases and cancer. |
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