Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants |
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| Authors: | Zhuang Jimmy J Hunter Craig P |
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| Affiliation: | Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. |
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| Abstract: | Gene knockdown by RNA interference (RNAi) in Caenorhabditis elegans is readily achieved by feeding bacteria expressing double-stranded RNA (dsRNA). Enhanced RNAi (Eri) mutants facilitate RNAi due to their hypersensitivity to dsRNA. Here, we compare eight Eri mutants for sensitivity to ingested dsRNA, targeting a variety of tissue-specific genes. |
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