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Asymmetric synthesis of novel alpha-amino acids with beta-branched side chains |
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| Authors: | Zhang Minsheng Porte Alex Diamantidis George Sogi Kimberly Kubrak Dennis Resnick Lynn Mayer Scott C Wang Zheng Kreft Anthony F Harrison Boyd L |
| Institution: | Wyeth Research, CN 8000, Princeton, NJ 08543, USA. zhangm8@wyeth.com |
| Abstract: | An asymmetric synthesis of alpha-amino acids with novel beta-branched side chains has been implemented. The syntheses feature a p-toluenesulfinylimine induced chiral Strecker approach and were found to be applicable to the introduction of both aliphatic and aromatic beta-branched sidechains for preparation of previously unknown alpha-amino acids. |
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