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Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the metal binding group |
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| Authors: | Smith Helen K Beckett R Paul Clements John M Doel Sheila East Stephen P Launchbury Steven B Pratt Lisa M Spavold Zoë M Thomas Wayne Todd Richard S Whittaker Mark |
| Institution: | British Biotech Pharmaceuticals Limited, Watlington Road, Oxford OX4 6LY, UK |
| Abstract: | A series of analogues of the potent peptide deformylase (PDF) inhibitor BB-3497 containing alternative metal binding groups was synthesised. Enzyme inhibition and antibacterial activity data for these compounds revealed that the bidentate hydroxamic acid and N-formyl hydroxylamine structural motifs represent the optimum chelating groups on the pseudopeptidic BB-3497 backbone. |
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