Genetic Mapping and ENU Mutagenesis |
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Authors: | David R Beier Bruce J Herron |
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Institution: | (1) Genetics Division, Brigham and Women s Hospital, Harvard Medical School, MA, USA |
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Abstract: | ENU mutagenesis is a potent means to generate novel mutations in the mouse, and the further investigation of these mutations can be logistically demanding. Determination of the map position of a mutation early in its characterization can be extremely useful. We describe how the use of interval haplotype analysis can facilitate this with even small numbers of affected progeny. |
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Keywords: | ENU haplotype mapping interval mapping mapping a phenotypic trait mouse mutagenesis |
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