Allostatic Load Model Associated with Indoor Environmental Quality and Sick Building Syndrome among Office Workers |
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| Authors: | Chien-Cheng Jung Hsiu-Hao Liang Hui-Ling Lee Nai-Yun Hsu Huey-Jen Su |
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| Affiliation: | 1. Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan city, Taiwan.; 2. Department of Chemistry, College of Science and Engineering, Fu Jen Catholic University, New Taipei city, Taiwan.; Tsinghua University, China, |
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| Abstract: | This study investigates whether indoor environmental quality (IEQ) influences allostatic load (AL) and whether AL can be a predictor for sick building syndrome (SBS). We also assessed and compared the associations between AL and SBS versus 8-hydroxydeoxyguanosine (8-OHdG) and SBS. A total of 115 office workers from 21 offices completed self-reported SBS questionnaires, and provided 11 biomarkers for their AL. Multiple linear regressions and logistic regression analysis were applied to examine the correlations between IEQ and AL or 8-OHdG and between AL or 8-OHdG and SBS, respectively. Our data revealed that the neuroendocrine system was correlated with CO2, the difference between indoor and outdoor CO2 levels (dCO2), and the indoor-outdoor ratio of CO2 (CO2 I/O). Metabolic system effects were associated with illumination. The relationships between illumination, CO2, dCO2, CO2 I/O and 8-OHdG were consistent with those and AL in specific systems. Furthermore, we found that risks for SBS syndromes were related with neuroendocrine and metabolic system of the AL. 8-OHdG was associated with eye dryness or irritation, eye tiredness and vomiting. We conclude that IEQ significantly influences AL and that AL can be a predictor for reporting SBS with information on system-specific effects. |
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