Identification of signaling components required for the prediction of cytokine release in RAW 264.7 macrophages |
| |
| Authors: | Sylvain Pradervand Mano R Maurya Shankar Subramaniam |
| |
| Affiliation: | (1) Bioinformatics and Data Coordination Laboratory, Alliance for Cellular Signaling, San Diego Supercomputer Center, University of California at San Diego, Gilman Drive, La Jolla, CA 92093, USA;(2) Department of Bioengineering, University of California at San Diego, Gilman Drive, La Jolla, CA 92093, USA;(3) Department of Chemistry and Biochemistry, University of California at San Diego, Gilman Drive, La Jolla, CA 92093, USA |
| |
| Abstract: | Background Release of immuno-regulatory cytokines and chemokines during inflammatory response is mediated by a complex signaling network. Multiple stimuli produce different signals that generate different cytokine responses. Current knowledge does not provide a complete picture of these signaling pathways. However, using specific markers of signaling pathways, such as signaling proteins, it is possible to develop a 'coarse-grained network' map that can help understand common regulatory modules for various cytokine responses and help differentiate between the causes of their release. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
