Cu2+-induced permeability of the Escherichia coli cytoplasmic membrane] |
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Authors: | V S Lebedev E Iu De?nega T A Kuzovnikova Iu I Fedorov |
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Institution: | Institute of Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia. |
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Abstract: | Cu(2+)-induced permeability of cytoplasmic membranes of Escherichia coli for different cations and neutral molecules of saccharose was estimated by studying their effect on cell plasmolysis during uncharged exchange of cytoplasmic K+ ions by periplasmic space cations. The addition of copper resulted in the exchange of K+ ions by periplasmic Na+, Tris+, streptomycin2+, Cu2+, Ca2+, Mg2+, Cd2+, and Mn2+. It is concluded that Cu(2+)-induced conducting pathways in bacterial membranes are hydrophilic channels with a radius of approximately 0.5 nm and a nonselective permeability for different cations. |
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