Clinical impact of dosimetric changes for volumetric modulated arc therapy in log file-based patient dose calculations |
| |
| Institution: | 1. Department of Radiology, Takeda General Hospital, Aizuwakamatsu, Japan;2. Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan;3. Department of Radiation Oncology, Tokai University School of Medicine, Isehara, Japan;1. Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, Spain;2. Servicio de Radiofísica, Hospital Universitario Virgen Macarena, Sevilla, Spain;3. Instituto de Física, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile;4. Istituto Nazionale di Fisica Nucleare, Frascati, Italy;1. CELIA, Centre Laser Intenses et Applications, Université de Bordeaux-CNRS-CEA, F-33400 Talence, France;2. Department of Radiotherapy, Institut Bergonié, Comprehensive Cancer Center, F-33076 Bordeaux, France;1. German Cancer Research Center (DKFZ), Division of Medical Physics in Radiation Oncology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;2. National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany;3. Heidelberg University Hospital, Department of Radiation Oncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany;4. Advacam s.r.o., Na Balkáně 2075/70, 130 00 Praha 3, Czech Republic;5. Institute of Experimental and Applied Physics, Czech Technical University in Prague, Horská 3a/22, 12800 Prague 2, Czech Republic |
| |
| Abstract: | PurposeA log file-based method cannot detect dosimetric changes due to linac component miscalibration because log files are insensitive to miscalibration. Herein, clinical impacts of dosimetric changes on a log file-based method were determined.Methods and materialsFive head-and-neck and five prostate plans were applied. Miscalibration-simulated log files were generated by inducing a linac component miscalibration into the log file. Miscalibration magnitudes for leaf, gantry, and collimator at the general tolerance level were ±0.5 mm, ±1°, and ±1°, respectively, and at a tighter tolerance level achievable on current linac were ±0.3 mm, ±0.5°, and ±0.5°, respectively. Re-calculations were performed on patient anatomy using log file data.ResultsChanges in tumor control probability/normal tissue complication probability from treatment planning system dose to re-calculated dose at the general tolerance level was 1.8% on planning target volume (PTV) and 2.4% on organs at risk (OARs) in both plans. These changes at the tighter tolerance level were improved to 1.0% on PTV and to 1.5% on OARs, with a statistically significant difference.ConclusionsWe determined the clinical impacts of dosimetric changes on a log file-based method using a general tolerance level and a tighter tolerance level for linac miscalibration and found that a tighter tolerance level significantly improved the accuracy of the log file-based method. |
| |
| Keywords: | Radiotherapy Volumetric modulated arc therapy Log file Patient-specific quality assurance |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
