Phase-contrast imaging for body composition measurement |
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| Institution: | 1. Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230027, China;2. National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230027, China;3. Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Science, Shanghai 201800, China;4. Experimental Center of Engineering and Material Science, University of Science and Technology of China, Hefei 230027, China;1. Petroleum Systems Engineering, Faculty of Engineering and Applied Science, University of Regina, Regina, Saskatchewan S4S 0A2, Canada;2. Institute for Energy, Environment and Sustainable Communities, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada;1. Chair of Biomedical Physics, Technical University of Munich, James-Franck-Str. 1, 85748 Garching, Germany;2. Institute of Mathematics, University of Graz, Heinrichstraße 36, 8010 Graz, Austria;3. Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany;4. School of Mathematical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom;1. Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistr. 15, 81377 München, Germany;2. Department of Physics and Institute of Medical Engineering, Technische Universität München, James-Franck-Straße 1, 85748 Garching, Germany;3. Medical Radiation Physics, Lund University, 22185 Lund, Sweden;4. Molecular Oncology Unit, Philipps-University Marburg, D-35032 Marburg, Germany;5. Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munich, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany |
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| Abstract: | PurposeIn this paper, we propose a novel method for human body composition measurement, especially for the bone mineral density (BMD) measurement. The proposed method, using the absorption and differential phase information retrieved from X-ray grating-based interferometer (XGBI) to measure the BMD, has potential to replace dual-energy X-ray absorptiometry (DEXA), which is currently widely used for body composition measurement.MethodsThe DEXA method employs two absorption images acquired at two different X-ray spectra (high energy and low energy) to calculate the human body composition. In this paper, a new method to calculate BMD using a single X-ray measurement is proposed. XGBI is a relatively new X-ray technique that provides absorption, phase and scattering information simultaneously using a single X-ray spectrum. With the absorption and differential phase information retrieved from XGBI, BMD can be measured using only one single X-ray spectrum. Numerical simulations are performed with a body phantom of bone (Cortical, ICRU-44) surrounded by soft tissue (Soft, ICRU-44). BMD is calculated with both the DEXA method and the proposed method.ResultsResults show that BMD can be measured accurately with the proposed method; moreover, better signal-to-noise ratio (SNR) is obtained compared to DEXA.ConclusionWith the proposed method, BMD can be measured with XGBI setup. Further, the proposed method can be realized using current X-ray phase-contrast imaging (XPCI) apparatus without any hardware modification, suggesting that this technique can be a promising supplementary function to current XPCI equipment. |
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| Keywords: | X-ray phase-contrast imaging Body composition measurement |
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