Clinical application of MOSkin dosimeters to rectal wall in vivo dosimetry in gynecological HDR brachytherapy |
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| Affiliation: | 1. Medical Physics Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy;2. Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia;3. Department of Physics, Università degli Studi di Milano, and INFN, Milan, Italy;4. Radiation Oncology 2 Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy;5. St George Cancer Care Center, Kogarah, NSW, Australia;6. Radiation Oncology Unit, Ente Ospedaliero Cantonale, Bellinzona, Switzerland;7. Medical Physics Unit, Ente Ospedaliero Cantonale, Bellinzona, Switzerland;1. Francis H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts;2. Centre for Medical Radiation Physics, University of Wollongong, New South Wales, Australia;1. Servicio de Radiofísica y Protección Radiológica, Consorcio Hospitalario Provincial de Castellón, Avda. Dr. Clará, 19, Castellón de la Plana 12002, Spain;2. Servicio de Oncología Radioterápica, Consorcio Hospitalario Provincial de Castellón, Avda. Dr. Clará, 19, Castellón de la Plana 12002, Spain;1. Department of Radiation Oncology, Complejo Hospitalario Universitario de Albacete (CHUA), Albacete, Spain;2. Department of Radiation Oncology, Hospital Son Espases, Palma de Mallorca, Spain;3. Gynecological Cancer Unit, Radiation Oncology Department, ICMHO, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain;4. Unidad de Medicina Molecular, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Albacete, Spain;5. Unidad asociada de Biomedicina, UCLM-CSIC, Albacete, Spain;6. Department of Radiation Oncology, Hospital Universitari Sant Joan, Reus, Spain;1. Medical Physics Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital, Guishan Dist., Taoyuan City 333, Taiwan;2. Particle Physics and Beam Delivery Core Laboratory, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Guishan, Taoyuan 333, Taiwan;3. Department of Medical Imaging and Radiological Sciences, Chang Gung University, Guishan Dist., Taoyuan City 333, Taiwan;4. Department of Radiation Oncology, Chang Gung Memorial Hospital, Guishan, Taoyuan 333, Taiwan;5. National Space Organization, 8F, No.9, Prosperity 1st Rd., Hsinchu Science Park, Hsinchu 33378, Taiwan |
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| Abstract: | PurposeThree MOSkins dosimeters were assembled over a rectal probe and used to perform in vivo dosimetry during HDR brachytherapy treatments of vaginal cancer. The purpose of this study was to verify the applicability of the developed tool to evaluate discrepancies between planned and measured doses to the rectal wall.Materials and methodsMOSkin dosimeters from the Centre for Medical Radiation Physics are particularly suitable for brachytherapy procedures for their ability to be easily incorporated into treatment instrumentation. In this study, 26 treatment sessions of HDR vaginal brachytherapy were monitored using three MOSkin mounted on a rectal probe. A total of 78 measurements were collected and compared to doses determined by the treatment planning system.ResultsMean dose discrepancy was determined as 2.2 ± 6.9%, with 44.6% of the measurements within ±5%, 89.2% within ±10% and 10.8% higher than ±10%. When dose discrepancies were grouped according to the time elapsed between imaging and treatment (i.e., group 1: ≤90 min; group 2: >90 min), mean discrepancies resulted in 4.7 ± 3.6% and 7.1 ± 5.0% for groups 1 and 2, respectively. Furthermore, the position of the dosimeter on the rectal catheter was found to affect uncertainty, where highest uncertainties were observed for the dosimeter furthest inside the rectum.ConclusionsThis study has verified MOSkin applicability to in-patient dose monitoring in gynecological brachytherapy procedures, demonstrating the dosimetric rectal probe setup as an accurate and convenient IVD instrument for rectal wall dose verification. Furthermore, the study demonstrates that the delivered dose discrepancy may be affected by the duration of treatment planning. |
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| Keywords: | HDR brachytherapy Vaginal cancer Solid state dosimetry |
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