Metabolomic profile in hyperthyroid patients before and after antithyroid drug treatment: Correlation with thyroid hormone and TSH concentration |
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| Affiliation: | 1. Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Cagliari, Italy;2. Department of Medical Sciences and Public Health, University of Cagliari, 09042 Monserrato, Cagliari, Italy;1. Department of Cardiology, Guang''anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;2. Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100029, China;3. Department of Cardiology, Guang''anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;4. School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China;5. Department of Cardiology, Guang''anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;6. Editorial department, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;7. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;1. Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;2. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;3. Department of Pathology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;1. Department of General Internal Medicine, Oregon Health & Science University, Portland;2. Department of Rheumatology, Oregon Health & Science University, Portland;1. Laboratorio de Termodinámica de Soluciones, Departamento de Química, Universidad de los Andes, Bogotá, D.C., Colombia;2. Chemistry Department, Murdoch University, Murdoch, WA 6150, Australia |
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| Abstract: | Hyperthyroidism (HT) is characterized by an intense metabolic impact which affects the lipid, carbohydrate and amino acids metabolism, with increased resting energy expenditure and thermogenesis. Metabolomics is a new comprehensive technique that allows to capture an instant metabolic picture of an organism, reflecting peculiar molecular and pathophysiological states. The aim of the present prospective study was to identify a distinct metabolomic profile in HT patients using 1H NMR spectroscopy before and after antithyroid drug treatment. This prospective study included 15 patients (10 female, 5 male) who were newly diagnosed hyperthyroidism. A nuclear magnetic resonance (1H NMR) based analysis was performed on plasma samples from the same patients at diagnosis (HypT0) and when they achieved euthyroidism (HypT1). The case groups were compared with a control group of 26 healthy volunteers (C). Multivariate statistical analysis was performed with Partial Least Squares-Discriminant Analysis (PLS-DA). PLS-DA identified a distinct metabolic profile between C and untreated hyperthyroid patients (R2X 0.638, R2Y 0.932, Q2 0.783). Interestingly, a significant difference was also found between C and euthyroid patients after treatment (R2X 0.510, R2Y 0.838, Q2 0.607), while similar cluster emerged comparing HypT0 vs HypT1 patients. This study shows that metabolomic profile is deeply influenced by hyperthyroidism and this alteration persists after normalization of thyrotropin (TSH) and free thyroid hormone (FT3, FT4) concentration. This suggests that TSH, FT3 and FT4 assays may not be insufficient to detect long lasting peripheral effects of the thyroid hormones action. Further studies are needed to clarify whether and to what extent the evaluation of metabolomics profile may provide relevant information in the clinical management of hyperthyroidism. |
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| Keywords: | Metabolomics Hyperthyroidism Biomarkers Multivariate statistical analysis |
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