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Targeted protein knockdown using small molecule degraders
Affiliation:1. Arvinas LLC, New Haven, CT 06511, United States;2. Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, United States;3. Department of Chemistry, Yale University, New Haven, CT 06520, United States;4. Department of Pharmacology, Yale University, New Haven, CT 06520, United States;1. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd, Pudong, Shanghai 201210, China;2. Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, United States;1. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA;2. Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;3. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA;4. Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA;5. Department of Cancer Biology and Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA;6. Departments of Chemistry, Pharmacology, and Molecular, Cellular and Development Biology, Yale University, New Haven, CT 06511, USA;7. Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 136-791, Republic of Korea;8. KU-KIST Graduate School of Converging Science and Technology, Seongbuk-gu, Seoul 136-713, Republic of Korea;9. Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA;1. Technical University Dortmund, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Straße 4a, 44227 Dortmund, Germany
Abstract:
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