Comparison between new-generation SiPM-based and conventional PMT-based TOF-PET/CT |
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| Institution: | 1. Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan;2. School of Health Science, International University of Health and Welfare, Ohtawara, Japan;3. Faculty of Health Science, Hokkaido University of Science, Sapporo, Japan;4. Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan;1. CELIA, Centre Laser Intenses et Applications, Université de Bordeaux-CNRS-CEA, F-33400 Talence, France;2. Department of Radiotherapy, Institut Bergonié, Comprehensive Cancer Center, F-33076 Bordeaux, France;1. Biostructure and Bioimaging Institute (IBB), National Research Council of Italy (CNR), Rome, Italy;2. University of Rome “La Sapienza”, S. Andrea Hospital, Rome, Italy;1. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran;3. Chronic Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. PET/CT and Cyclotron Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Massachusetts General Hospital, Harvard Medical School, Boston, USA;1. Agnes Scott College, Department of Physics and Astronomy, 141 E College Ave, Decatur, GA 3003, United States;2. University of Verona, Department of Computer Science, Strada Le Grazie 15, Verona 37134, Italy;3. San Raffaele Scientific Institute, Experimental Imaging Center, Via Olgettina N. 60, Milan 20182, Italy;1. Medical Physics Department, University Hospital “Maggiore della Carità”, Novara, Italy;2. Medical Physics Department, Ospedale S.Andrea, Asl5 Spezzino, La Spezia, Italy;3. Nuclear Medicine Department, Ospedale S.Andrea, Asl5 Spezzino, La Spezia, Italy;4. Nuclear Medicine Department, University Hospital, “Maggiore della Carità”, Novara, Italy |
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| Abstract: | PurposeThis study aimed to determine whether the SiPM-PET/CT, Discovery MI (DMI) performs better than the PMT-PET/CT system, Discovery 710 (D710).MethodsThe physical performance of both systems was evaluated using NEMA NU 2 standards. Contrast (%), uniformity and image noise (%) are criteria proposed by the Japanese Society of Nuclear Medicine (JSNM) for phantom tests and were determined in images acquired from Hoffman and uniform phantoms using the DMI and D710. Brain and whole-body 18F]FDG images were also acquired from a healthy male using the DMI and D710.ResultsThe spatial resolution at 1.0 cm off-center in the DMI and D710 was 3.91 and 4.52 mm, respectively. The sensitivity of the DMI and D710 was 12.62 and 7.50 cps/kBq, respectively. The observed peak noise-equivalent count rates were 185.6 kcps at 22.5 kBq/mL and 137.0 kcps at 29.0 kBq/mL, and the scatter fractions were 42.1% and 37.9% in the DMI and D710, respectively. The D710 had better contrast recovery and lower background variability. Contrast, uniformity and image noise in the DMI were 61.0%, 0.0225, and 7.85%, respectively. These outcomes were better than those derived from the D710 and satisfied the JSNM criteria. Brain images acquired by the DMI had better grey-to-white matter contrast and lower image noise at the edge of axial field of view.ConclusionsThe DMI offers better sensitivity, performance under conditions of high count rates and image quality than the conventional PMT-PET/CT system, D710. |
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| Keywords: | Silicon-photomultiplier National Electrical Manufactured Association Instrumentation Physical performance Image quality |
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