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Biosensor-assisted transcriptional regulator engineering for Methylobacterium extorquens AM1 to improve mevalonate synthesis by increasing the acetyl-CoA supply
Affiliation:1. Key Laboratory for Industrial Biocatalysis, Ministry of Education; Department of Chemical Engineering, Center for Synthetic & System Biology, Tsinghua University, Beijing 100084, China;2. School of Life Sciences, Qingdao Agricultural University, Qingdao 266109, China;3. College of Chemistry and Molecular Engineering, Peking University, Beijing 10084, China;1. Department of Chemistry and Biomolecular Sciences, Macquarie University, NSW, Australia;1. Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, Bielefeld, Germany;2. SINTEF Materials and Chemistry, Department of Biotechnology and Nanomedicine, Trondheim, Norway;3. NTNU, Norwegian University of Science and Technology, Department of Biotechnology, Trondheim, Norway;1. Department of Chemical & Biological Engineering and Advanced Biomanufacturing Centre, The University of Sheffield, Sir Robert Hadfield Building, Mappin Street, Sheffield S1 3JD, United Kingdom;2. Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States;3. Institut für Molekulare Mikrobiologie und Biotechnologie, Westfälische Wilhelms-Universität, Münster D-48149, Germany;4. Environmental Science Department, King Abdulaziz University, Jeddah, Saudi Arabia
Abstract:
Keywords:QscR regulation  Biosensor  Cyclic pathway  Acetyl-CoA  Mevalonate
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