Towards breast cancer rotational radiotherapy with synchrotron radiation |
| |
| Affiliation: | 1. Imaging Department, University Centre Hospitals of Coimbra (CHUC), Praceta Mota Pinto, 3000-075 Coimbra, Portugal;2. Radiation Oncology Department, University Centre Hospitals of Coimbra (CHUC), Coimbra, Portugal;3. Imaging Department, Centre Hospitals of Algarve, Faro, Portugal;1. Institute for Diagnostic and Interventional Radiology, Georg-August University, Göttingen, Germany;2. Center for Electrophysiology, Heart Center, Am Klinikum Links der Weser, Bremen, Germany; Department of Cardiology, Asklepios Klinik, St. Georg, Hamburg, Germany;3. Department of Mathematical Sciences, The University of Texas at Dallas, Richardson, TX, USA;4. Department of Nuclear Medicine, Hanover Medical School, Hannover, Germany;1. Arachne Consulting, Sherman Oaks, CA, 91423, United States;2. Aerospace Engineering and Engineering Mechanics, University of Texas at Austin, Austin, TX 78712, United States |
| |
| Abstract: | PurposeWe performed the first investigations, via measurements and Monte Carlo simulations on phantoms, of the feasibility of a new technique for synchrotron radiation rotational radiotherapy for breast cancer (SR3T).MethodsA Monte Carlo (MC) code based on Geant4 toolkit was developed in order to simulate the irradiation with the SR3T technique and to evaluate the skin sparing effect in terms of centre-to-periphery dose ratio at different energies in the range 60–175 keV. Preliminary measurements were performed at the Australian Synchrotron facility. Radial dose profiles in a 14-cm diameter polyethylene phantom were measured with a 100-mm pencil ionization chamber for different beam sizes and compared with the results of MC simulations. Finally, the dose painting feasibility was demonstrated with measurements with EBT3 radiochromic films in a phantom and collimating the SR beam at 1.5 cm in the horizontal direction.ResultsMC simulations showed that the SR3T technique assures a tumour-to-skin absorbed dose ratio from about 7:1 (at 60 keV photon energy) to about 10:1 (at 175 keV), sufficient for skin sparing during radiotherapy. The comparison between the results of MC simulations and measurements showed an agreement within 5%. Two off-centre foci were irradiated shifting the rotation centre in the horizontal direction.ConclusionsThe SR3T technique permits to obtain different dose distributions in the target with multiple rotations and can be guided via synchrotron radiation breast computed tomography imaging, in propagation based phase-contrast conditions. Use of contrast agents like iodinated solutions or gold nanoparticles for dose enhancement (DE-SR3T) is foreseen and will be investigated in future work. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
