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Covalent inhibitors: an opportunity for rational target selectivity
Affiliation:1. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd, Pudong, Shanghai 201210, China;2. Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, United States;1. Center for Molecular Medicine, Molecular Cancer Research, University Medical Center Utrecht, The Netherlands;2. Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, San Francisco, CA, USA;1. Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK;2. Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK;3. Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O''Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK;4. Beactica AB, Box 567, 751 22 Uppsala, Sweden;5. Department of Chemistry-BMC, Uppsala University, 751 23 Uppsala, Sweden
Abstract:
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