PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt3 inhibition by promotion of PRC expression |
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| Authors: | Daniel G. Corum Dorea P. Jenkins James A. Heslop Lacey M. Tallent Gyda C. Beeson Jeremy L. Barth Rick G. Schnellmann Robin C. Muise-Helmericks |
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| Affiliation: | 1.Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina;2.Department of Pathology, Medical University of South Carolina, Charleston, South Carolina;3.Department of Bioengineering, Duke University, Durham, North Carolina;4.Department of Drug Discovery, Medical University of South Carolina, Charleston, South Carolina;5.Department of Pharmacy, University of Arizona, Tucson, Arizona |
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| Abstract: | |
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| Keywords: | Akt3/PKBγ , angiogenesis, endothelial cells, mitochondria, peroxisome proliferator– activated receptor γ coactivator-1 α , PGC-1α , Akt PKB, PPARGC1A, phosphodiesterases, PRC, Akt3 |
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