| 高分子药物缓释用壳聚糖微球的制备 |
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| 引用本文： | 辛嘉英 李冬. 高分子药物缓释用壳聚糖微球的制备[J]. 天然产物研究与开发, 1996, 8(3): 92-95 |
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| 作者姓名： | 辛嘉英 李冬 |
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| 作者单位： | 中国科学院兰州化学物理研究所，中国科学院兰州化学物理研究所，中国农科院兰州兽医研究所 兰州 730000，兰州 730000，兰州 730000 |
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| 摘 要： | 本文采用了先交联制备可溶胀的壳聚糖载体微球,后将模型高分子药物以被动吸咐方式担载在溶胀的微球内的两步法,制备缓释高分子药物微球,避免了高分子药物接触有机试剂引起的活性损失。
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| 关 键 词： | 壳聚糖 交联 微球 缓释 高分子药物 |
THE SYNTHESIS OF CHITOSAN MICROSPflERES FOR MACROMOLECULAR DRUGS SLOW-RELEASE |
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| Xin Jiaying,Zhang Fusheng. THE SYNTHESIS OF CHITOSAN MICROSPflERES FOR MACROMOLECULAR DRUGS SLOW-RELEASE[J]. Natural Product Research and Development, 1996, 8(3): 92-95 |
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| Authors: | Xin Jiaying Zhang Fusheng |
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| Abstract: | In this study the swellable chitosan microspheres were prepared by glutaraldehyed cross-linking reaction.Model macromolecular followed to be adsorbed into preformed swelling chitosan microsphcre. The two-step synthetic methed for macromolecular drugs slow-release microspheres avoid the problem of macromolecular drug,s biology activity is often compromised by organic agents. |
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| Keywords: | Chitasan cross-linking microspheres slow-release macromolecular drugs |
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