Requirement of Osteopontin in the migration and protection against Taxol-induced apoptosis via the ATX-LPA axis in SGC7901 cells |
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| Authors: | Rihua?Zhang Jing?Wang Shijie?Ma Zuhu?Huang Email author" target="_blank">Guoxin?ZhangEmail author |
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| Institution: | (1) Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China;(2) Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China |
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| Abstract: | Background Autotaxin (ATX) possesses lysophospholipase D (lyso PLD) activity, which converts lysophosphatidylcholine (LPC) into lysophosphatidic
acid (LPA). The ATX-LPA signaling axis has been implicated in angiogenesis, chronic inflammation and tumor progression. Osteopontin
(OPN) is an important chemokine involved in the survival, proliferation, migration, invasion and metastasis of gastric cancer
cells. The focus of the present study was to investigate the relationship between the ATX-LPA axis and OPN. |
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