Fluorometric measurement of tin-protoporphyrin in biological samples |
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Authors: | Creuza S. Simionatto Karl E. Anderson Shigeru Sassa George S. Drummond Attallah Kappas |
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Affiliation: | The Rockefeller University Hospital, 1230 York Avenue, New York, New York 10021 USA |
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Abstract: | Sn-protoporphyrin is a potent competitive inhibitor of heme oxygenase, can suppress neonatal and other forms of hyperbilirubinemia in laboratory animals, and represents a potential new approach to the treatment of neonatal jaundice in humans. In order to study the disposition of Sn-protoporphyrin in vivo we have developed a sensitive fluorometric method for the quantitation of this metalloporphyrin in biological samples. The method is sensitive to concentrations as low as 0.01 nmol/ml, and is specific for Sn-protoporphyrin even in the presence of other porphyrins such as protoporphyrin. |
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