Gas-liquid chromatographic determination of total phenylacetic acid in urine |
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| Authors: | Fabian Gusovsky Hector Sabelli Jan Fawcett John Edwards Javaid I. Javaid |
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| Affiliation: | 1. Department of Psychiatry, Rush Presbyterian St. Luke''s Medical Center, Chicago, Illinois 60612 USA;2. Illinois State Psychiatric Institute, Chicago, Illinois 60612 USA |
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| Abstract: | A gas-liquid chromatographic procedure to measure total phenylacetic acid in urine is described. The method is simple, rapid, and reliable. Normal subjects (N = 48) excreted 141.1 ± 10.1 mg/24 h. Untreated depressed patients (N = 42) excreted 102.77 ± 15.9 mg/24 h. The difference in the means is significant and supports the role of phenylacetic acid as a biological marker in certain kinds of mental illnesses. |
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| Keywords: | phenylacetic acid 2-phenylethylamine major depressive disorders |
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