Preparation of NG-monoethyl-l-arginine |
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Authors: | Yung-Bong Cho George Furst Woon Ki Paik |
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Institution: | 1. Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania 19140 USA;2. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA |
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Abstract: | NG-Monoethyl-l-arginine, a putative in vivo product after administration of the potent hepatocarcinogen l-ethionine to rats, has been chemically synthesized by coupling N-ethyl, S-methylthiopseudouronium iodide with α-amino-blocked l-ornithine. The structure of the compound as NG-monoethyl-l-arginine was confirmed by 13C NMR. Its elution time on an automatic amino acid analyzer, Rf values using thin-layer chromatography, and isoelectric point have been compared with those of NG-monomethyl-l-arginine. |
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