Sequence,tissue distribution and developmental changes in rat intestinal oligopeptide transporter |
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| Institution: | 1. Department of Clinical Nutrition, School of Medicine, Tokushima University, Tokushima 770, Japan;2. Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920, Japan;1. Instituto de Investigación e Ingeniería Ambiental and Escuela de Ciencia y Tecnología (UNSAM), Av. 25 de Mayo y Francia (C1650), San Martín, Buenos Aires, Argentina;2. CONICET, Argentina;3. Lab. Biológico-Lab. Química, INTI-Ambiente, Av. Gral Paz 5445 (B1650KNA), Buenos Aires, Argentina;4. Centro Atómico Bariloche - Complejo Tecnológico Pilcaniyeu, Comisión Nacional de Energía Atómica, Centro Atómico Bariloche, Av. E. Bustillo 9500 (8400), Bariloche, Rio Negro, Argentina;5. Universidad Tecnológica Nacional, Facultad Regional Buenos Aires, Extensión Áulica Bariloche, F.T. de Newbery 137 (8400), Bariloche, Rio Negro, Argentina;1. Department of Microbiology, University of Delhi South Campus, New Delhi 110021, India;2. School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand;3. Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK), Corrensstr. 3, 06466 Gatersleben, Germany;1. Department of Chemistry, Arignar Anna Govt Arts & Science College, Karaikal 609 605, India;2. Research and Development Centre, Bharathiar University, Coimbatore, 641 046, India;3. Institute of Low Temperature and Structure Research, Polish Academy of Sciences, 50–950, Wroclaw 2, P.O. Box 1410, Poland;4. School Sciences and Humanities, Vel Tech University, Chennai, 600 062, India;1. UMR CNRS 6112 LPG-BIAF, University of Angers, France;2. Department of Life and Environmental Sciences (Di.S.V.A.), Polytechnic University of Marche, Ancona, Italy;3. Department of Life and Environmental Sciences, University of Cagliari, Italy;4. Stazione Zoologica Anton Dohrn, Naples, Italy;5. CEFREM, CNRS-University of Perpignan Via Domitia, Perpignan, France;6. Esaip La Salle, St Barthélemy d''Anjou, France |
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| Abstract: | Complementary DNA clones encoding the rat PepT1 small-intestinal oligopeptide transporter were isolated from a jejunal library by cross-hybridization with a rabbit PepT1 cDNA probe. The cDNA sequence indicates that rat PepT1 is composed of 710 amino acids and shows 77% and 83% amino acid sequence identity with rabbit and human PepT1, respectively. Northern blot analysis detected rat PepT1 mRNA in the small intestine and kidney. Intestinal PepT1 mRNA levels were highest in 4-day-old rats, and then decreased reaching the adult level by day 28 after birth. These results indicate that the expressions of PepT1 gene change markedly during development. |
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