Fast habituation of the long-latency auditory evoked potential in the awake albino rat |
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| Affiliation: | 1. Division of Developmental and Behavioral Neurosciences, Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA;2. Division of Developmental of Behavioral Neurosciences, Department of Pediatrics, State University of New York at Buffalo, Buffalo, NY, USA;3. Behavioral Neuroscience Program, Department of Psychology, State University of New York at Buffalo, Buffalo, NY, USA;1. Key Laboratory of Functional Inorganic Material Chemistry (MOE), School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, Heilongjiang, China;2. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, Liaoning, China;1. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia;2. Institute for Condensed Matter Physics, 1 Svientsitskii Str., UA-79011 Lviv, Ukraine;3. SoftServe Inc., 2d Sadova Str., UA-79021 Lviv, Ukraine;1. Key Laboratory of Solar Thermal Energy and Photovoltaic System, Institute of Electrical Engineering, Chinese Academy of Sciences, Zhongguancun, Haidian, Beijing, 100190, China;2. China Electric Power Research Institute, Nanjing, 210003, Jiangsu, China;3. University of Chinese Academy of Sciences, Beijing, 100049, China;1. Key Laboratory of Clean Dyeing and Finishing Technology of Zhejiang Province, Shaoxing University, Shaoxing, 312000, China;2. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China |
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| Abstract: | Fast habituation of the long-latency, vertex-recorded auditory evoked potential (AEP) peaks in humans was first described by Callaway (1973) as a reduction in AEP amplitude that occurs to the second of a pair of acoustic stimuli when both stimuli are presented with an interstimulus interval (ISI) of no more than 10 sec. When acoustic stimuli are presented in pairs with an ISI of 2 sec and an interpair interval (IPI) of approximately 10 sec, reduction in amplitude to the second tone occurs by as much as 30–50%. Fast habituation may depend somewhat on a subject's anticipation of the stimulus and on other factors related to attention and orienting. Studies in our laboratory have demonstrated this amplitude decrement to the second tone of a pair in human infants, children and adults and have explored the implications of this finding with respect to attentional processes and the allocation of cerebral resources. In the present investigation we describe an animal model of fast habituation. Here, vertex-recorded AEPs were obtained to paired tone stimuli delivered to awake adult male Sprague-Dawley rats chronically implanted with skull electrodes. Findings showed: (a) an AEP wave form with 8 distinct peaks, (b) for one component there was a marked decrement in amplitude from tone 1 to tone 2 in recordings obtained from an electrode placed slightly to the right of midline, and (c) that there were no significant differences in peak latencies across tones. This methodology may further our understanding of fast habituation in humans and may prove useful for studies of attention, orienting, and resource allocation using techniques that are not possible for use with human subjects. |
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