Novel molecular classification of colorectal cancer and correlation with survival |
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Authors: | Fayaz Hussain Mangi Tanweer Ahmed Shaikh Daniele Soria Ali Muhammad Waryah Ikram Din Ujjan Jawaid Naeem Qureshi Binafsha Manzoor Syed |
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Affiliation: | 1. Department of Clinical Research, Medical Research Centre, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan;2. Department of Pathology, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan;3. School of Computing, University of Kent, Canterbury CT2 7NF, United Kingdom;4. Department of Molecular Biology and Genetics, Medical Research Centre, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan;5. Department of Surgery, Indus Medical College, Tando Mohammad Khan, Pakistan |
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Abstract: | IntroductionColorectal cancer (CRC) is one of the most common cancers worldwide. This study was designed to evaluate biological patterns, explore molecular classification and correlate with survival outcome in treatment naïve CRC patients.MethodsOver 11 years consecutive series of 435 CRC patients were operated on as primary surgical therapy. A total of 201 CRC patients were included, whose complete set of clinical information was available, and their good quality tumour blocks were retrieved. Immunohistochemistry was used for tumour analysis, and partitional clustering was performed using R software for cluster analysis.ResultsThe median age was 43 (range 10–85) years; adenocarcinoma was the most commonly seen histological type. The great majority had positive CK20, CEA, E-Cadherin, Ki67, CDX2, and p53 expression. There were four distinct molecular classes found, whereas Ki67, CDX2, and p53 play the main role in partitioning. Younger age negatively impacted survival; overall and disease-specific survival was 26 months only with 50 months’ longest survival.ConclusionColorectal cancer is a biologically heterogeneous disease with at least four distinct molecular patterns, where cell proliferation and gene repair mechanisms appear to play the key role. |
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