Inhibitory effect of hederagenin on Streptococcus pneumoniae pneumolysin in vitro |
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| Affiliation: | 1. Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China;2. Hospital of Stomatology, Jilin University, Changchun 130021, China;3. Shandong Jinzhuji Pharmaceuticals Co. Ltd., Jinan 271100, Shandong, China;1. Departamento de Microbiología e Inmunología, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Ruta Nacional 36, Km 601, X5804ZAB Río Cuarto, Córdoba, Argentina;2. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina;1. Dept. Infection Biology, Institute of Infection and Global Health, University of Liverpool, L3 5RF, UK;2. Centre Eugène Marquis, Université Rennes-1, INSERM U1242, Rennes, France;3. Graduate Studies Office, Department of Research, Innovation and Graduate Studies, Waterford Institute of Technology, X91 K0EK, Ireland;1. Department of Blood Transfusion, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;2. The Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;3. Department of Intensive Care Unit, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;1. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China;2. Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China;3. Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China |
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| Abstract: | Streptococcus pneumoniae is an important pathogen that causes otitis media, pneumonia, meningitis and bacteremia. As an important virulence factors of S. pneumoniae, pneumolysin (PLY) can penetrate cell membranes and lead to cell lysis and inflammation, which is one of the main causes of infection and damage of S. pneumoniae. Therefore, using pneumolysin as a target to study its inhibitors can provide a new treatment strategy for pneumococcal disease. This study analyzed the inhibitory effect of the natural compound hederagenin on PLY in vitro. The results show that hederagenin has great potential as a new strategy for the treatment of pneumococcal diseases. |
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| Keywords: | Pneumolysin Hederagenin Anti-virulence |
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