Prognostic and pathogenic role of CXC motif ligand 16 in sepsis |
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| Institution: | 1. Department of Blood Transfusion, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;2. The Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;3. Department of Intensive Care Unit, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;1. Departamento de Microbiología e Inmunología, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Ruta Nacional 36, Km 601, X5804ZAB Río Cuarto, Córdoba, Argentina;2. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina;1. Immunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Paraíba, 58051-900, Brazil;2. Post-graduation Program in Biotechnology, Center of Biotechnology of Federal University of Paraíba, João Pessoa, Paraíba, 58051-900, Brazil;3. Molecular Biology of Cancer and Infectious Diseases Laboratory of Post-Graduation Program on Parasite Biology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 58078-970, Brazil;4. Research Institute for Drugs and Medicines, Federal University of Paraiba, João Pessoa, Paraíba, 58051-900, Brazil;5. Department of Infectious Disease, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, London, W12 0NN, United Kingdom;6. Department of Immunology and Inflammation, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, London, W12 0NN, United Kingdom;1. Laboratorio de Inmunoquímica y Biotecnología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Buenos Aires, Argentina;2. Servicio Bacteriología, Departamento Laboratorio del Instituto Nacional de Epidemiología “Dr. Juan H. Jara” (INE), Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS), Ministerio de Salud de la Nación, Argentina;3. Programa de Microbiología y Micología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile;1. Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, South Korea;2. Department of Biochemistry, Chungnam National University, Daejeon, 34134, South Korea;3. Department of Biomolecular Science, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, 34113, South Korea;4. Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, 52828, South Korea |
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| Abstract: | Chemokine CXC motif ligand 16 (CXCL16) is an important mediator that has been shown to participate in various human diseases. The role of CXCL16 in the immunopathology of sepsis remains unidentified. In this study, we found that human patients with sepsis had significantly higher soluble levels of serum CXCL16 than healthy volunteers on day of intensive care unit (ICU) admission. Soluble CXCL16 remained significantly up-regulated in the patients with sepsis, which correlated with disease severity. Furthermore, nonsurvivors displayed significantly higher admission levels of soluble CXCL16 compared with survivors of septic patients. Soluble CXCL16 levels revealed significant prognostic value for 28-day mortality, and CXCL16 was shown to be an independent predictor of 28-day mortality in the patients with sepsis. In a murine model of cecal ligation and puncture (CLP)-induced nonsevere sepsis, supplementation of recombinant CXCL16 protein could increase sepsis-induced mortality and tissue injury. Conversely, neutralizing CXCL16 by anti-CXCL16 monoclonal antibody could decrease mortality and tissue injury in CLP-induced severe sepsis. However, CXCL16 did not affect the ability of these mice to clear bacteria in CLP. Taken together, CXCL16 could be related to sepsis not only as a novel biomarker of prognosis, but also as a potential target for therapeutic intervention. |
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| Keywords: | CXCL16 Sepsis Inflammation Infection Prognosis |
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