Exploring the role of cathepsin in rheumatoid arthritis |
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| Institution: | 1. Chitkara College of Pharmacy, Chitkara University, Punjab, India;2. Natural & Medical Sciences Research Centre, University of Nizwa, Nizwa, Oman;3. Adjunct Professor, Amity Institute of Pharmacy, Amity University, Haryana, India;4. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraidah, Saudi Arabia;5. Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraidah, Saudi Arabia;6. Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania |
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| Abstract: | Rheumatoid arthritis (RA) is a chronic inflammatory disease which is marked by leukocytes infiltration inside synovial tissue, joints and also inside synovial fluid which causes progressive destruction of joint cartilage. There are numerous genetical and lifestyle factors, responsible for rheumatoid arthritis. One such factor can be cysteine cathepsins, which act as proteolytic enzymes. These proteolytic enzyme gets activated at acidic pH and are found in lysosomes and are also termed as cysteine proteases. These proteases belong to papain family and have their elucidated role in musculoskeletal disorders. Numerous cathepsins have their targeted role in rheumatoid arthritis. These proteases are secreted through various cell types which includes matrix metalloproteases and papain like cysteine proteases. These proteases can potentially lead to bone and cartilage destruction which causes an immune response in case of inflammatory arthritis. |
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| Keywords: | Cathepsin Inflammation Rheumatoid arthritis Cysteine protease Matrix-metalloprotease |
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