Possible Trichosporon asahii urinary tract infection in a critically ill COVID-19 patient |
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Affiliation: | 1. Hospital de Guarnição de Natal, Rio Grande do Norte, Brazil;2. Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil;3. Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil |
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Abstract: | BackgroundTrichosporon asahii, an emerging fungal pathogen, has been frequently associated with invasive infections in critically ill patients.Case reportA 74-year-old male patient diagnosed with COVID-19 was admitted to an Intensive Care Unit (ICU). During hospitalization, the patient displayed episodes of bacteremia by Staphylococcus haemolyticus and a possible urinary tract infection by T. asahii. While the bacterial infection was successfully treated using broad-spectrum antibiotics, the fungal infection in the urinary tract was unsuccessfully treated with anidulafungin and persisted until the patient died.ConclusionsWith the evolving COVID-19 pandemic, invasive fungal infections have been increasingly reported, mainly after taking immunosuppressant drugs associated with long-term broad-spectrum antibiotic therapy. Although Candida and Aspergillus are still the most prevalent invasive fungi, T. asahii and other agents have emerged in critically ill patients. Therefore, a proper surveillance and diagnosing any fungal infection are paramount, particularly in COVID-19 immunocompromised populations. |
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Keywords: | COVID-19 SARS-CoV-2 Antifungal resistance Emergent fungi Urinary tract infection COVID-19 SARS-CoV-2 Resistencia a los antimicóticos Hongos emergentes Infección del tracto urinario |
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