A potential double role of anti-Lewis X antibodies in Helicobacter pylori-associated gastroduodenal diseases |
| |
Authors: | Rudnicka W Czkwianianc E Płaneta-Małecka I Jurkiewicz M Wiśniewska M Cieślikowski T Rózalska B Wadström T Chmiela M |
| |
Affiliation: | Department of Infectious Biology, Institute for Microbiology and Immunology, University of Lodz, Poland. rudw@biol.uni.lodz.pl |
| |
Abstract: | In this study, we found Lewis X (Le(x)) determinants on 68% of Helicobacter pylori isolates from patients with chronic gastroduodenal diseases. Anti-Le(x) IgG were detected more frequently in the sera from dyspeptic children and adults (45 and 46%), with or without proved (culture) H. pylori infection, than in the sera from healthy individuals (14% and 25%). In contrast, the prevalence of anti-Le(x) IgM was higher in the groups of healthy individuals than in the groups of dyspeptic patients. Moreover, anti-Le(x) monoclonal antibody of IgM class enhanced the uptake of Le(x)(+) but not Le(x)(-) H. pylori isolates by phagocytes. In the sera from some dyspeptic patients, we detected Le(x)-anti-Le(x) IgG immune complexes (Le(x) ICs). There was a great difference between children and adults as regards the presence of Le(x) ICs. The immune complexes were found in the sera from nine out of 29 (27%) H. pylori-infected and three out of eight (37%) uninfected adult dyspeptic patients. In comparison, Le(x)-anti-Le(x) IgG ICs were detected only for two out of 18 (11%) H. pylori-infected children. Le(x) ICs were not found in the sera from healthy individuals. Our results suggest that anti-Le(x) IgM may play a protective role in H. pylori infections. In contrast, anti-Le(x) IgG and particularly Le(x)-anti-Le(x) IgG ICs might contribute to the pathogenesis of chronic H. pylori infections. |
| |
Keywords: | Helicobacter pylori Lewis X Lewis X–anti-Lewis X immune complex |
本文献已被 PubMed 等数据库收录! |
|