| 皮质醇对离体牛蛙交感神经节B细胞胆碱能突触传递的快速作用 |
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| 作者姓名： | Yi BD Ma B Xing BR |
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| 作者单位： | 1. 贵阳医学院生理教研室,贵阳,550004
2. 第二军医大学生理教研室,上海,200433 |
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| 基金项目： | 军队医药项目,96Z035, |
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| 摘 要： | 在离体灌流的牛蛙交感神经节标本上,电刺激节前纤维,细胞内记录Ｂ细胞的电活动,观察给予皮质醇对Ｂ细胞突触传递作用。主要结果有：（１）电刺激节前纤维,细胞内记录１７０个Ｂ细胞的动作电位,给予皮质醇后０．５￣３ｍｉｎ内,５２个Ｂ细胞的突触传递发生脱漏甚至完全阻断,有明显的量效关系。甾体激素胞内受体阻断剂ＲＵ３８４８６可部分阻断这种作用。（２）蛋白合成抑制剂放线菌酮不能阻断皮质醇的快速阻断作用。（３）阿托
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| 关 键 词： | 皮质醇 交感神经节 快速作用 突触传递 |
Rapid effects of hydrocortisone on the cholinergic synaptic transmission of B neurons in bullfrog sympathetic ganglia |
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| Yi BD,Ma B,Xing BR.Rapid effects of hydrocortisone on the cholinergic synaptic transmission of B neurons in bullfrog sympathetic ganglia[J].Acta Physiologica Sinica,1999,0(2):147-152. |
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| Authors: | Yi B D Ma B Xing B R |
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| Institution: | Department of Physiology, Second Military Medical University, Shanghai 200433. |
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| Abstract: | Rapid effects
of hydrocortisone 21hemisuccinate (Fsuc) on cholinergic synaptic transmission of B neurons in
bullfrog sympathetic ganglia (BFSG) were studied with intracellular recording technique in vitro.
The main results are as follows: (1)Fsuc blocked cholinergic synaptic transmission of 52 B
neurons within 053 min, which was concentrationdependent and partially suppressed by the
cytoplasm receptor antagonist of steroid hormones, RU38486; (2)after protein synthesis was
suppressed by actidione, the above effect persisted; and (3)the effect of Fsuc could be
potentiated by atropine. All these results suggest that the Fsuc induced rapid effects of
cholinergic synaptic transmission of B neurons in BFSG may be mediated by nongenomic
mechanisms. |
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| Keywords: | hydrocortisone 21hemisuccinate bullfrog sympathetic ganglia rapid effect synaptic transmission |
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