Acetaminophen protects human erythrocytes against oxidative stress |
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| Authors: | J Van der Zee G J Mulder J Van Steveninck |
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| Institution: | Center for Bio-Pharmaceutical Sciences, Division of Toxicology, Leiden, The Netherlands. |
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| Abstract: | Acetaminophen protects human erythrocytes against various modes of oxidative stress. Protection against ozone-induced damage can be explained by a direct scavenging reaction between the drug and ozone. With t-butylhydroperoxide acetaminophen appeared to be an effective scavenger of radicals, generated in secondary reactions. The protection by acetaminophen against t-butylhydroperoxide- and hydrogen peroxide-induced lipid peroxidation and K+-leakage can be explained along these lines. In all cases the protective effect of acetaminophen was attended with covalent binding of acetaminophen to membrane proteins. |
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