Expedient synthesis of N-Z-pyroglutamyl-amino acid derivatives |
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| Authors: | Katritzky Alan R Angrish Parul Todadze Ekaterina Ghiviriga Ion |
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| Institution: | Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu |
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| Abstract: | N-Z-pyroglutamyl pseudopeptides 3a-c are shown to be conveniently prepared from glutamyl-bis-Bt 1a by cyclization of an N-terminal glutamic acid residue. Structures are supported by 2D NMR studies and by comparison with the same products prepared by direct coupling of the C-terminus activated N-pGlu 1b and free amino acids 2a-c. |
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