Double vision: pigment genes do more than just color |
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Authors: | Ambegaokar Surendra S Jackson George |
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Affiliation: | Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA. |
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Abstract: | The use of P element collections led to the discovery of unanticipated effects from common genetic background mutants white, brown, and rosy in our previously reported model of tauopathy that expresses full-length human tau in the fly eye, in which mutant rosy suppresses mutant white and brown worsening of tau-induced toxicity (Ambegaokar & Jackson, 2010, Genetics, v. 186, p. 435-42). Here we discuss further possible effects of mini-white and evidence for autophagy as a mediator of white enhancement of tau toxicity. |
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