A new approach to assessing the validity of indels in algorithmic pair alignments |
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| Authors: | V. O. Polyanovsky M. A. Roytberg V. G. Tumanyan |
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| Affiliation: | (1) Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia;(2) Institute of Mathematical Problems in Biology, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia |
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| Abstract: | Analysis of the structure of indels in algorithmic versus evolutionary alignments based on a set of inequalities confirms the conclusions from numerical modeling. For the more divergent sequences (PAM > 60), the tested aligning algorithm (SW) tends to increase the mean length of indels and decrease their number. |
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| Keywords: | pairwise alignment insertion deletion |
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