Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+) |
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Authors: | W Korytowski C C Felix B Kalyanaraman |
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Abstract: | Oxidase electrode measurements have shown that the neurotoxin metabolite 1-methyl-4-phenyl-2,3-dihydropyridinium autoxidizes to hydrogen peroxide and 1-methyl-4-phenylpyridinium in a reaction promoted by iron chelates. The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity is discussed in the light of these findings. |
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