Stimulated recovery of perturbed haematopoiesis by inhibition of prostaglandin production — promising therapeutic strategy |
| |
Authors: | Michal Hofer Milan Pospíšil |
| |
Institution: | (1) Laboratory of Experimental Hematology, Institute of Biophysics, Academy of Sciences of the Czech Republic, CZ-612 65 Brno, Czech Republic |
| |
Abstract: | Inhibitors of prostaglandin production, designated as classical non-steroidal anti-inflammatory drugs (NSAIDs) and acting
on the base of non-selective inhibition of cyclooxygenases, have been found in numerous studies to potentiate recovery of
perturbed haematopoiesis by removing the negative feedback control mediated by prostaglandins. However, classical NSAIDs show
pronounced undesirable gastrointestinal side effects, which limits the possibility of their utilization for various pathophysiological
states including myelosuppression. Specific cyclooxygenase-2 (COX-2) inhibitors, targeted at selective inhibition of this
inducible cyclooxygenase isoform and having much better gastrointestinal side effect profile, have been found in recent studies
to retain the haematopoiesis-stimulating effects of classical NSAIDs. These results suggest that the indication spectrum of
selective COX-2 inhibitors may be extended to the indication of myelosuppression of various etiology. Combining the anti-tumour
and haematopoiesis-stimulating activities in a single COX-2 inhibitor may have a positive clinical impact. |
| |
Keywords: | Non-steroidal anti-inflammatory drugs cyclooxygenase-2 haematopoiesis |
本文献已被 SpringerLink 等数据库收录! |
|